Towards single particle imaging of human chromosomes at SACLA
نویسندگان
چکیده
منابع مشابه
Sequential Single Shot X-ray Photon Correlation Spectroscopy at the SACLA Free Electron Laser.
Hard X-ray free electron lasers allow for the first time to access dynamics of condensed matter samples ranging from femtoseconds to several hundred seconds. In particular, the exceptional large transverse coherence of the X-ray pulses and the high time-averaged flux promises to reach time and length scales that have not been accessible up to now with storage ring based sources. However, due to...
متن کاملSingle-shot arrival timing diagnostics for a soft X-ray free-electron laser beamline at SACLA.
Arrival timing diagnostics performed at a soft X-ray free-electron laser (FEL) beamline of SACLA are described. Intense soft X-ray FEL pulses with one-dimensional focusing efficiently induce transient changes of optical reflectivity on the surface of GaAs. The arrival timing between soft X-ray FEL and optical laser pulses was successfully measured as a spatial position of the reflectivity chang...
متن کاملSingle particle X-ray diffractive imaging.
In nanotechnology, strategies for the creation and manipulation of nanoparticles in the gas phase are critically important for surface modification and substrate-free characterization. Recent coherent diffractive imaging with intense femtosecond X-ray pulses has verified the capability of single-shot imaging of nanoscale objects at suboptical resolutions beyond the radiation-induced damage thre...
متن کاملOverview of the SACLA facility
In March 2012, SACLA started user operations of the first compact X-ray free-electron laser (XFEL) facility. SACLA has been routinely providing users with stable XFEL light over a wide photon energy range from 4 to 15 keV and an ultrafast pulse duration below 10 fs. The facility supports experimental activities in broad fields by offering high-quality X-ray optics and diagnostics, as well as re...
متن کاملCo-localization of cell surface receptors at high spatial resolution by single-particle fluorescence imaging.
Dual-wavelength single-particle fluorescence imaging has been used to quantify the co-localization of receptors and/or ligands on cells by widefield microscopy. Methods for correction of chromatic aberration and identification of submicroscopic artefacts are presented, with data for the lipopolysaccharide/CD14 and MHC class II/CD74 systems.
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ژورنال
عنوان ژورنال: Journal of Physics B: Atomic, Molecular and Optical Physics
سال: 2015
ISSN: 0953-4075,1361-6455
DOI: 10.1088/0953-4075/48/24/244007